Search results for "Cellular metabolism"
showing 6 items of 6 documents
Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism
2020
Immunological and metabolic processes are inextricably linked and important for maintaining tissue and organismal health. Manipulation of cellular metabolism could be beneficial to immunity and prevent metabolic and degenerative diseases including obesity, diabetes, and cancer. Maintenance of a normal metabolism depends on symbiotic consortium of gut microbes. Gut microbiota contributes to certain xenobiotic metabolisms and bioactive metabolites production. Gut microbiota-derived metabolites have been shown to be involved in inflammatory activation of macrophages and contribute to metabolic diseases. Recent studies have focused on how nutrients affect immunometabolism. Polyphenols, the seco…
Dietary polyphenols for managing cancers: What have we ignored?
2020
Abstract Although the chemoprevention and anti-cancer activities of dietary polyphenols have been evidenced through both in vitro and in vivo studies, most of the human clinical trials were unsuccessful or even harmful. Debates on the beneficial roles of dietary polyphenols in cancer therapy are increasing. Many dietary polyphenols studies are conducted by in vitro experiments, but the nature of these studies does not consider the complexity of metabolic processes that are present in vivo. These can often cause instability in the dietary polyphenols, thereby leading to unsuccessful extrapolation into animal or human studies. Dietary polyphenols often have low bioavailability, which is mainl…
A Bio-Inspired Cognitive Agent for Autonomous Urban Vehicles Routing Optimization
2017
Autonomous urban vehicle prototypes are expected to be efficient even in not explicitly planned circumstances and dynamic environments. The development of autonomous vehicles for urban driving needs real-time information from vehicles and road network to optimize traffic flows. In traffic agent-based models, each vehicle is an agent, while the road network is the environment. Cognitive agents are able to reason on the perceived data, to evaluate the information obtained by reasoning, and to learn and respond, preserving their self-sufficiency, independency, self-determination, and self-reliance. In this paper, a bio-inspired cognitive agent for autonomous urban vehicles routing optimization…
Effects of UV and Blue Light on the Bipotential Changes in Etiolated Hypocotyl Hooks of Dwarf Beans
1980
One of the most complex topics to study in biology is the ability of organism to perceive, code, transmit, and integrate environmental information, which is used to direct the cellular metabolism and developmental processes occurring. The detection of different wavelengths of light by specific mechanism plays a key role in plant development. Although great progress has been made in the study of plant photoreceptor pigments, some pigment systems are understood better than others.
Proteomic fingerprinting of apple fruit, juice, and cider via combinatorial peptide ligand libraries and MS analysis
2018
Combinatorial peptide ligand libraries coupled to MS was applied to extensively map the proteome of apple fruit, and to detect its presence in commercial apple juice and cider to evaluate their authenticity and genuineness. Using the Uniprot_Malus database, 96 proteins were detected in apples, among which 30 proteins were specifically captured via combinatorial peptide ligand libraries. Next, three proteins, previously recognized in fruits, were found in apple juice, which were involved in cellular metabolism of fruit maturation and in allergenic reactions. On the other hand, only one Malus allergen was identified in cider beads eluate, demonstrating that the industrial processes did not pr…
METABOLIC NETWORKS ROBUSTNESS: THEORY, SIMULATIONS AND RESULTS
2011
Metabolic networks are composed of several functional modules, reproducing metabolic pathways and describing the entire cellular metabolism of an organism. In the last decade, an enormous interest has grown for the study of tolerance to errors and attacks in metabolic networks. Studies on their robustness have suggested that metabolic networks are tolerant to errors, but very vulnerable to targeted attacks against highly connected nodes. However, many findings on metabolic networks suggest that the above classification is too simple and imprecise, since hub node attacks can be by-passed if alternative metabolic paths can be exploited. On the contrary, non-hub nodes attacks can affect cell …